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| MacIver,R.H.; Stewart,R.D.; Backer,C.L.; Tsao,S.; Harrington,D.A.; Mavroudis,C.. |
| The atrioventricular (AV) node is permanently damaged in approximately 3% of congenital heart surgery operations, requiring implantation of a permanent pacemaker. Improvements in pacemaker design and in alternative treatment modalities require an effective in vivo model of complete heart block (CHB) before testing can be performed in humans. Such a model should enable accurate, reliable, and detectable induction of the surgical pathology. Through our laboratory’s efforts in developing a tissue engineering therapy for CHB, we describe here an improved in vivo model for inducing chronic AV block. The method employs a right thoracotomy in the adult rabbit, from which the right atrial appendage may be retracted to expose an access channel for the AV node. A... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Atrioventricular node; Heart block; Ablation; Tissue engineering; Regenerative medicine; In vivo model. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000200012 |
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| Ezquer,Marcelo E; Ezquer,Fernando E; Arango-Rodríguez,Martha L; Conget,Paulette A. |
| Currently, one of the main threats to public health is diabetes mellitus. Its most detrimental complication is diabetic nephropathy (DN), a clinical syndrome associated with kidney damage and an increased risk of cardiovascular disease. Irrespective of the type of diabetes, DN follows a well-known temporal course. The earliest detectable signs are microalbuminuria and histopathological changes including extracellular matrix deposition, glomerular basement membrane thickening, glomerular and mesangial expansion. Later on macroalbuminuria appears, followed by a progressive decline in glomerular filtration rate and the loss of glomerular podocytes, tubulointerstitial fibrosis, glomerulosclerosis and arteriolar hyalinosis. Tight glycemic and hypertension... |
| Tipo: Journal article |
Palavras-chave: Regenerative medicine; Diabetes mellitus; Diabetic nephropathy; Multipotent mesenchymal stromal cells; Mesenchymal stem cells. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300010 |
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